Две неща, едното е статия, представяща изследване по повод ICSI/In vitro и малформации, дано да ви е полезна.
а по повод "трябва", Pesheck не съм сигурна, че съм казала, че трябва, мисля, че казах, че за мен това не е алтернатива. не зная как по-ясно да го напиша.
IVF and ICSI increases risk of malformations
Largest study of its kind finds a major congenital malformation in 4.24% of the children conceived through IVF and ICSI assisted reproductive technology (ART)
By Nicky Broyd
WebMD Health News
Reviewed by Dr Rob Hicks
14th June 2010 - The largest study of its kind has concluded children born after IVF and ICSI assisted reproduction are at greater risk of congenital malformations. The findings will be announced today at the annual conference of the European Society of Human Genetics. The doctors behind the French study say couples considering undergoing assisted reproductive technology (ART) treatment should be informed about the increased risk of congenital malformation.
The Human Fertilisation & Embryology Authority (HFEA) estimates that around one in six UK couples, approximately 3.5 million people, experience some form of fertility problems at some point in their lives.
The French study
Dr. Géraldine Viot, a clinical geneticist at the Maternité Port Royal hospital, Paris and colleagues, conducted a survey in 33 French centres registered for ART, around one third of the total number in France. The study looked at children born after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) from these clinics from 2003 to 2007: 15 162 children in total.
Viot said: "We found a major congenital malformation in 4.24% of the children compared with the 2-3% that we had expected from previous published studies.
“This higher rate” she said, “was due in part to an excess of heart diseases and malformations of the uro-genital system. This was much more common in boys. Among the minor malformations, we found a five times higher rate of angioma, benign tumours made up of small blood vessels on or near the surface of the skin. These occurred more than twice as frequently in girls than boys."
However, the scientists say, their results are a long way from the 11% of major malformations that have been reported by some studies. "Given that our study is the largest to date, we think that our data are more likely to be statistically representative of the true picture", says Viot.
Possible causes
Voit believes the origins of the malformations are probably multiple: "We need more research in order to understand the relationship between embryo culture media, timing of embryo transfer, the effects of ovarian stimulation, the use of ICSI, where sperm is injected directly into the egg, freezing of gametes and embryos and these disorders.
The researchers were surprised that the average age of the parents of children born with malformations was not statistically different from other parents in the study.
"We estimate that in France some 200,000 children have been born after ART” says Voit “and therefore a malformation rate of this magnitude is a public health issue. It is important that all doctors and also politicians are informed about this. We also need to follow up all children born after ART and to put much more effort into trying to understand which of the procedures involved is
implicated in this problem."
The latest UK figures available for patients undergoing ART are for 2007 when the HFEA says 36,861 patients had assistance with reproduction.
The scientists are now trying to find out the origin of parental infertility for each child born after IVF and ICSI who has been affected by major malformation or epigenetic disorders. "With this knowledge, we can better establish the origin of the malformation and whether it is more likely to be related to parental infertility or the ART procedure itself", said Viot.
"At a time when infertility is increasing and more and more couples need to use ART to conceive, it is vitally important that we find out as much as we can about what is causing malformations in these children, not only so that we can try to counteract the problem but also in order for health services to be able to plan for their future needs."
